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王哲

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发表于 2017-6-30 15:07:44 | 显示全部楼层 |阅读模式

王哲

主任医师


王哲,男,1970年1月生,内蒙包头人,第四军医大学基础部病理学与病理生理学教研室暨西京医院病理科教授、主任,博士生导师,获评陕西省“三秦人才”。主要从事外科病理诊断以及临床病理研究10余年。擅长淋巴造血系统、软组织和男性泌尿生殖系统病理诊断。
在病理诊断工作中发现、命名并报道了新的软组织肿瘤类型Inflammatory Monomorphic Undifferentiated Sarcoma;在国际杂志中报道了多种罕见的肿瘤和病例;在研究中发现药物诱导白血病凋亡途径中溶酶体蛋白酶Cathepsin D的转位是连接溶酶体与线粒体凋亡途径之间的重要分子;发现乳腺癌的新辅助化疗可以影响肿瘤Her-2免疫组化状态的改变,但不影响其基因扩增的变化;发现了核糖体蛋白激酶RSK4是肾细胞癌独立的预后预测因子。阐明了间变型弥漫大B细胞淋巴瘤的临床和遗传学特点。发表SCI论文60余篇,其中第一作者和通讯作者20余篇。获得国家自然科学基金资助6项。主编专著3部,主译专著1部,参编5部。
关键词:淋巴瘤;肾细胞癌;蛋白激酶;肿瘤遗传学;表观遗传学
主要学历:
1987.09-1993.07 第四军医大学学员五大队医疗系本科
1995.09-1997.07第四军医大学基础部病理学教研室读硕士
1997.08-2000.06第四军医大学基础部病理学教研室读博士
主要工作经历:
1993.08-1995.08 新疆疏勒县解放军第十二医院小儿科医师
2000.07-2005.06第四军医大学病理学教研室讲师
2005.10-2007.07美国明尼苏达大学Hormel研究所博士后(With Dr. Johnny Lu)
2007.10-今     第四军医大学病理学与病理生理学教研室副教授、教授、副主任、主任
学习经历:
2007.07-2007.09 美国佛蒙特大学病理科访问教授(with Dr. Sharon Mount)
2007.09        美国佛罗里达奥兰多佛罗里达医院病理科访问医师(with Dr. M Joe Ma)
2007.09        美国佛罗里达奥兰多地区医院病理科访问医师(with Dr. Shuan Li)
2012.06-2012.09  香港伊利沙伯医院病理科进修(with Dr. John K.C Chan)
学术任职:
中华医学会病理学分会常委
中华医学会病理学分会青年委员会副主任委员
中华医学会病理学分会淋巴造血病理学组委员
中华医学会病理学分会泌尿生殖病理学组委员
中国医师协会病理学分会常委
中国抗癌协会肿瘤病理专业委员会常委
中国抗癌协会淋巴瘤专业委员会病理组委员
中国研究型医院学会病理学分会副主委
中国医疗促进委员会病理学分会副主委
中国病理学工作者委员会副主委
全军病理学会副主任委员
陕西省抗癌协会淋巴瘤专业委员会副主任委员
中央军委保健委员会会诊专家
2010-2018年 美国加拿大病理学会会员
2013-2020年 国际泌尿病理学会会员
《诊断病理学杂志》副主编
肿瘤生物学国家重点实验室生物信息学单元负责人
国际杂志Apoptosis、Cancer Biomarker、APMIS、Breast Cancer Research Treatment、PlosONE、Histopathology、Tumor Biology、J oncopathology、Diagnostic Pathology等12种杂志同行审稿人
获得的国家自然科学基金(负责):
1、国家自然科学基金面上项目《新的白血病细胞K562分化相关基因dif13的表达及功能的研究》(2001-2003)30000198
2、白血病细胞分化相关基因dif14不同异位剪接mRNA的克隆和功能研究(2005-2007)30470873
3、酪氨酸蛋白激酶Fyn 磷酸化雄激素受体的生物学意义研究(2008-2010)30771120
4、前列腺癌雄激素信号抑制剂 PCARI-15 作用机制的研究(2011-2013)81072103
5、核糖体S6蛋白激酶RSK4在胃腺癌发病机理中的研究(2013-2016) 81272651
6、JAK2磷酸化PBK/TOPK Tyr74位点在伯基特淋巴瘤中的作用研究(2016-2019)81570180
参加国际会议:
1、Ectopic cervical anaplastic ependymoma. International Association of Pathology annual meeting 2005, Beijing P.R China 2005, Aug 15-18 (Poster)
2、Discovery of decursin from Korean Angelica gigas as a novel non-steroidal anti-androgen. Cancer Drugs R&D, San Francisco CA 2006, Feb 9-10 (Poster)
3、Role of AKT and p38MAPK in apoptosis and cell cycle effects of methyl selenium in microvascular endothelial cells. AACR 2006, Washington DC, 2006, Apr 1-5 (Poster)
4、Mechanism of methylseleninic acid against vascular endothelial proliferation and tumor angiogenesis.  AACR 2007, Los Angeles, CA, 2007, Apr 14-18 (Poster)
5、Renal cell carcinoma and RSK4. International Association of Pathology annual meeting 2011, GU Session. Taipei 2011, May 22-26 (20 min lecture)
6. Unusual renal mesenchymal tumor. International Association of Pathology annual meeting 2013, GU Session. Bushan Korea 2013, Sep 03-05 (20 min lecture and Convenor)
7. EBV Associated T/NK Proliferative Disease with with Bowel Involvement and Prominent Eosinophilic Abscess. The 5th Asian Hematopathology Symposium. Nagoya, Japan. Jan. 24–26, 2014 (15 min lecture and Chairman of session II)
8. A Case of Plasmacytoma with Crystal-Storing Histiocytosis Showing t(4;14)(p16;q32) Translocation Involving the FGFR3 and IgH Gene. The 5th Asian Hematopathology Symposium. Nagoya, Japan. Jan. 24–26, 2014 (10 min oral poster pesentation)
9. Stat-3 phosphorylation status in extranodal NK/T cell lymphoma. 18th NK-Cell Tumor Research Meeting, Shinagawa, Tokyo, February 21, 2015 (20 min lecture)
10. Bi-Clonal plasma cell proliferation in angioimmunoblastic T-cell lymphoma: case report and review of literature. The 6th Asian Hematopathology Symposium. Seoul, Korea, January 23, 2016 (lecture and Chairman)
11. Anaplastic Variant of Diffuse Large B-cell Lymphoma Displays Intricate Genetic Alterations and Distinct Biological Features, Annual Meeting of the United States and Canadian Academy of Pathology. March 4, 2017, in San Antonio, Texas USA, Best abstract award of CAPA

通讯作者和第一作者SCI论文:(共发表SCI论文60余篇)
1、Wang Z, Liang R, Huang GS, et al. Glucosamine sulfate–induced apoptosis in chronic myelogenous leukemia K562 cells is associated with translocation of cathepsin D and downregulation of Bcl-xL Apoptosis. 2006 11(10):1851(通讯)
2、Wang Z, Li Q, Huang GS, et al. Clinical report of congenital lymphatic malformations and partial gigantism of the hands associated with a heterogeneous karyotype. Am J of Med Genet. 2005, 132A(1): 106-107 (通讯)
3、Wang Z, Huang GS, Yan PS, et al. Ectopic cervical anaplastic ependymoma. Pathol Int. 2005; 55(12):781(通讯)
4、Gong W, Cheng H, Yan Q, Huang G, Luo P, Wang Z. Serous Papillary Cystadenocarcinoma Arising From Autografted Ovary of the Abdominal Wall. Int J Surg Pathol. 2010; 18(5):398-400 (通讯)
5、Wang Z, Huang GS, et al. Inflammatory monomorphic undifferentiated sarcoma with distinct clinical and pathological features.  A “new” entity?. Pathology, 2011;43(1):48 (通讯)
6、Wang Z, Hu H, Li G, et al. Methylseleninic acid inhibits microvascular endothelial G(1) cell cycle progression and decreases tumor microvessel density. Int J Cancer. 2007, 122(1):15. (通讯)
7、Wang Z, Lee H, Hu H, et al. Anti-androgen receptor signaling and prostate cancer inhibitory effects of sucrose- and benzophenone compounds. Pharm Res. 2009;26(5):1140-8 (2011JCR 4.456, 5y-4.138)
8、Wang Z, Lee H, Wang L, et al. Persistent P21Cip1 induction mediates G1 cell cycle arrest by methylseleninic acid in DU145 prostate cancer cells. Curr Cancer Drug Targ  2010; 10(3):307-18 (2011JCR 4.771, 5y-4.683)
9、Yin ZY, Fan LN, Huang GS, Wang HC, Wang Z. The possible role of ribosomal protein S6 kinase 4 in the senescence of endothelial progenitor cells in diabetes mellitus. Cardiovascular Diabetology 2012, 11:12 (通讯)
10、Lv Y, Li P, Zheng J, Wang L, Yun J, Huang G, Yan Q, Li Z, Luo P, Li S, Harn L, Yi J, Wang Z. Nodular Histiocytic Aggregates in the Greater Omentum of Patients With Ovarian Cancer. Int J Surg Pathol 2012 20(2):178-84(通讯)
11、Liu TT, Li PF, Wang Z. Submucosal tumor of stomach. Gastroenterology, 2012, 143(3):e18-9 (通讯)
12、Peifeng Li, Yingmei Wang, Qingqing Zhang, Yixiong Liu, Yang Lv, Zhe Wang. A noninvasive mucinous cystic neoplasm with intermediate-grade dysplasia of the pancreas and extensive squamous metaplasia: a case report with clinicopathological correlation. Diagnostic Pathology. 2012, 7:89 (通讯)
13、Peifeng Li, Tantan Liu, Yingmei Wang, Shuai Shao, Weichen Zhang, Yang Lv, Jun Yi, Zhe Wang. Influence of neoadjuvant chemotherapy on HER-2/neu status in invasive breast cancer. Clin Breast Cancer. 2013, 13(1):53-60 (通讯)
14、L Fan, P Li, Z Yin, G Fu, D J Liao, Y Liu, J Zhu, Y Zhang, L Wang, Q Yan, Y Guo, C Shao, G Huang and Z Wang. Ribosomal s6 protein kinase 4: a prognostic
factor for renal cell carcinoma. Br J Cancer, 2013, 109:1137–1146 (通讯)
15、Yixiong Liu,Peifeng Li, Ying Guo,Linni Fan, Lu Wang, Jin Zhu, Gaosheng Huang,Qingguo Yan, Zhe Wang. A Unique Composite Follicular Lymphoma and Mantle Cell Lymphoma with a Mixed Cell Pattern and Aggressive Course. Am J Clin Pathol. 2014;141:737-41. (IF 2.565)(通讯)
16. Peifeng Li, Guangbin Cui, Yingmei Wang, Ming Geng and Zhe Wang. Multicystic meningioangiomatosis. BMC Neurology 2014, 14:32(通讯)
17. Lv Y, Liu Y, Li X, Yan Q, Wang Z. Plasmacytoma with crystal-storing histiocytosis exhibiting FGFR3 and IgH translocation. Pathology. 2015; 47(1):82-5. (通讯)
18. Guo S, Yan Q, Rohr J, Wang Y, Fan L, Wang Z. Erdheim-Chester disease involving the breast-a rare but important differential diagnosis. Hum Pathol. 2015 Jan;46(1):159-64(通讯)
19. Yang Lv, Ning Wang, Yixiong Liu, Xia Li, Linni Fan, Mingyang Li, Lu Wang, Zhou Yu, Qingguo Yan, Ying Guo, Shuangping Guo, Lichun Wei, Mei Shi, Zhe Wang. Tumor invasion depth is a useful pathologic assessment for predicting outcomes in cervical squamous cell carcinoma after neoadjuvant radiotherapy. Diagnostic Pathology. 2015; 10(1):200(共同通讯)
20. Li J, Wang Z. The pathology of unusual subtypes of prostate cancer. Chin J Cancer Res 2016;28(1):130-143. (通讯)
21. Yang Z, Yu L, Wang Z. PCA3 and TMPRSS2-ERG gene fusions as diagnostic biomarkers for prostate cancer. Chin J Cancer Res 2016;28(1):65-71. (通讯)
22. Shuangping Guo, Yingmei Wang, Joseph Rohr, Chaoliang Fan, Qinglong Li, Xia Li, Zhe Wang. Solid papillary carcinoma of the breast: A special entity needs to be distinguished from conventional invasive carcinoma avoiding over-treatment. The Breast, 2016; 26:67-72 (通讯)
23. Shuangping Guo, Chaoliang Fan, Joseph Rohr, Linni Fan, Yingmei Wang, Mingyang Li, Xia Li, Ying Guo, Qingguo Yan, Lu Wang, Zhe Wang. A clinicopathologic study of paragangliomas of the urinary bladder: can the clinical behavior of the tumor be predicted? Histol Histopathol. 2016; 31(7):785-791(通讯)
24. Jin Zhu, Yuehua Zhang, Weichen Zhang, Wei Zhang, Linni Fan, Lu Wang, Yixiong Liu, Shasha Liu, Ying Guo, Yingmei Wang, Jun Yi, Qingguo Yan, Zhe Wang and Gaosheng Huang. MicroRNA 142-5p contributes to Hashimoto’s thyroiditis by targeting CLDN1. J Transl Med (2016) 14:166(共同通讯)
25. Shuangping Guo, Xia Li, Joseph Rohr, Yingmei Wang, Shirong Ma, Peng Chen and Zhe Wang. EZH2 overexpression in different immunophenotypes of breast carcinoma and association with clinicopathologic features. Diagnostic Pathology 2016, 11:41(通讯)
26. Guo S, Bai Q, Rohr J, Wang Y, Liu Y, Zeng K, Yu K, Zhang X, Wang Z.  Clinicopathological features of primary diffuse large B-cell lymphoma of the central nervous system – strong EZH2 expression implying diagnostic and therapeutic implication. APMIS, 2016, 124:1056-1062(通讯)
27. Mingyang Li, Yixiong Liu, Yingmei Wang, Gang Chen, Qiongrong Chen, Hualiang Xiao, Fang Liu, Chubo Qi, Zhou Yu, Xia Li, Linni Fan, Ying Guo, Qingguo Yan, Shuangping Guo, Zhe Wang. Anaplastic Variant of Diffuse Large B-cell Lymphoma Displays Intricate Genetic Alterations and Distinct Biological Features. Am J Surg Pathol, 2017 (通讯)


参与肿瘤病理诊断规范制定:


刘卫平、周小鸽、李小秋、王哲。淋巴瘤病理诊断规范,卫计委医院管理研究所,2015
主编、主译、参编的书籍:
主编《生物信息学概论》2002年,第四军医大学出版社
主译《外科病理取材图解指南》2009年,第四军医大学出版社
主审《病理学基础》中等医学专科学校“十一五”规划教材,2008年,第四军医大学出版社
主编《西京医院病理科工作手册》 2012年  第四军医大学出版社
主编《肿瘤病理知识问答》  2016年  人民卫生出版社
参编《临床病理学》,2009年,人民卫生出版社
参编《病理学复习考试指导》,2010年,中国协和医科大学出版社


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